Certain low-volume, specialist assays are performed by a single laboratory for all clinicians irrespective of region. To order these tests contact the lab indicated below directly.
The following assays are NOT offered by East Genomics and should be ordered directly from the relevant laboratory using the paperwork available on this page:
| Test | Laboratory |
|---|---|
| Test NPM1 MRD rare transcripts (non-type A/B/D) | Laboratory South East GMS (Guy's Hospital) |
| Test NPM1 MRD | Laboratory South East GMS (Guy's Hospital) |
| Test BCR-ABL1 TKD mutation testing by NGS | Laboratory South East GMS (King's Hospital) |
| Test ALL MRD (paediatrics & TYA) | Laboratory South West GMS (Bristol) |
| Test TPMT and NUDT15 genotyping for 6-mercaptopurine (6-MP) dosing in acute lymphoblastic leukaemia (ALL) | Laboratory South West GMS (Bristol) |
| Test ALL MRD (adult) | Laboratory North Thames GMS (Bart's) |
| Test BCR-ABL1 rare (non-p210) transcripts | Laboratory North Thames GMS (Hammersmith) |
| Test KIT D816V high sensitivity testing (e.g. peripheral blood) | Laboratory Central & South GMS (Oxford) |
| Test FIP1L1-PDGFRA high sensitivity (MRD) | Laboratory Central & South GMS (Oxford) |
| Test Histiocytosis testing | Laboratory North East GMS |
AML MRD testing
Please note that for some regions where AML MRD testing has previously been sent to a different specialist laboratory, discussions are still underway to agree on transition arrangements including for historical patients.
Peripheral blood samples can be sent directly to the specialist laboratory by clinicians using the referral forms above.
Bone marrow samples will in most cases be sent to these specialist laboratories by the SIHMDS service. For RNA-based assays (e.g. AML tests, BCR-ABL1), samples require processing within ~48 hours. In some circumstances it will be necessary for clinicians to send samples directly to the specialist testing laboratory, for example because sampling towards the end of a week prevents immediate transfer from the SIHMDS to the specialist laboratory and local RNA extraction is either unavailable or will significantly delay turnaround times. Clinicians are advised to discuss pathways with their local SIHMDS.
South East GMS
South West GMS
North Thames GMS
National Adult ALL MRD Service – Essential Information for Service Users
The referral form can be found here. (opens in a new tab)