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East Genomics

Turn around times

For all our tests we are working to exceed the turn around times for Genetic/Genomic tests have been specified by NHS England.

The below table shows our ‘current’ turn-around times (August 2021), as well as the specified times that we are working towards at the Cambridge Laboratory of the East GLH. For those marked with an *, please see note below table on current turn-around times. We will update these times regularly and will also include the turn around times for our two local laboratories soon.

Sample reception
Our laboratory has been redesigned to aid rapid turnaround and high throughput of genomic tests

Clinical urgency

Urgent - ultra rapid (Rare Disease and Cancer)

Non-urgent advice: Example tests

Rare diseases - QF-PCR for rapid trisomy detection

Calendar days (target): 3 days

Meeting target: Yes

Rare diseases - PCR-based tests for prenatal diagnosis (PND)

Calendar days (target): 3 days

Meeting target: Yes

Cancer - Urgent haemato-oncology FISH/RT-PCR (e.g. BCR/ABL1, PML/RARA)

Calendar days (target): 3 days

Meeting target: Yes

DPYD

Calendar days (target): 5 days

Meeting target: Yes (average 2 days)

Cystic Fibrosis carrier test (pregnancy) (CF EGB)

Calendar days (target): 7 days

Meeting target: No - currently national kit issues (estimate 15 days)

Cystic Fibrosis diagnostic test (newborn)

Calendar days (target): 7 days

Meeting target: No - currently national kit issues (estimate 15 days)

Clinical urgency

Urgent - rapid (Rare Disease and Cancer)

Non-urgent advice: Example tests

Rare diseases - Microarray for prenatal / urgent postnatal (e.g. neonatal referrals)

Calendar days (target): 14 days

Meeting target: Yes

Rare diseases - Southern blot tests where the result is needed urgently for Pre-natal diagnosis

Calendar days (target): 14 days

Meeting target: No (estimate 20 days)

Rare diseases - PCR-based tests for predictive testing

Calendar days (target): 14 days

Meeting target: No (17 days)

Confirmation of neonatal results (PCR results)

TBC

Carrier testing / familial variant testing required in context of pregnancy

Calendar days (target):

Meeting target: No (17 days)

Cancer - Urgent haemato-oncology karyotyping

Calendar days (target): 14 days

Meeting target: No (Karyotype: 27 days; Array 20 days)

Cancer - Mutation specific molecular pathology tests

Calendar days (target): 14 days

Meeting target: Yes

MSI testing (Lynch syndrome or immunotherapy)

Calendar days (target): 14 days

Meeting target: Yes

Cancer - MGMT promoter methlyation

Calendar days (target): 14 days

Meeting target: Yes

Cancer - MGMT promoter methlyation

Calendar days (target): 14 days

Meeting target: Yes

Cancer - Clonality

Calendar days (target): 14 days

Meeting target: Yes

Cancer - FISH for molecular pathology referrals

Calendar days (target): 14 days

Meeting target: Yes

Cancer - Chimerism

Calendar days (target): 14 days

Meeting target: No (17 days)

Clinical urgency

Urgent - complex rapid (Rare Disease and Cancer)

Non-urgent advice: Example tests

Urgent panels, gene screens (treatment / antenatal)

Calendar days (target): 21 days

Meeting target - tbc

Clinical urgency

Non-urgent - standard (Somatic Cancer)

Non-urgent advice: Example tests

Standard haemato-oncology karyotyping (e.g. MDS)

Calendar days (target): 21 days

Meeting target: No (74 days)

Haemato-oncology microarrays

Calendar days (target): 21 days

Meeting target: Yes

Standard molecular haemato-oncology tests

Calendar days (target): 21 days

Meeting target: tbc

NGS panels for haemato-oncology referrals

Calendar days (target): 21 days

Meeting target: No, significant delay *

NGS panels for molecular pathology referrals

Calendar days (target): 21 days

Meeting target: Y (often quicker)

Clinical urgency

Non-urgent - standard (Rare Disease)

Non-urgent advice: Example tests

Standard paediatric or fetal loss microarray

Calendar days (target): 42 days

Meeting target: No - currently 83 days (12 weeks)

Postnatal karyotyping (e.g. fertility or familial microarray follow-up)

Calendar days (target): 42 days

Meeting target: No - currently 10 weeks

Standard single gene and small gene panel (<10 genes) sequencing

Calendar days (target): 42 days

Meeting target: Y (often quicker) - except for R134 familia hypercholestrolemia

PCR based tests for diagnostic testing

Calendar days (target): 42 days

Meeting target: Yes

Known familial variants testing including diagnostic confirmation, segregation analysis and carrier testing

Calendar days (target): 42 days

Meeting target: Yes

Standard STR based analysis

Calendar days (target): 42 days

Meeting target: Yes

Clinical urgency

Non-urgent - complex standard (Rare Disease)

Non-urgent advice: Example tests

Large gene-panels (10 or more genes) for standard referral indications

Calendar days (target): 84 days

Meeting target: No, significant delay (average 150 days)*

Non-Invasive Pre-natal Testing (NIPT) and Whole Genome Sequencing (WGS)

  • The turnaround time for NIPT is seven days (currently outsourced).
  • WGS turn-around time is 84 days.

* Unfortunately for the tests marked with asterisk, we are experiencing significant delays to results. We are working hard to improve our results, though we will let you know of our expected turn-around times on referral. Please bear this in mind when speaking to your patient.

Notes:

  • PCR = polymerase chain reaction
  • STR = short tandem repeat